Name: Júlia Rabelo Santos Ferreira
Type: MSc dissertation
Publication date: 21/05/2021

Namesort descending Role
Luciane Bresciani Salaroli Advisor *

Examining board:

Namesort descending Role
Edson Theodoro dos Santos Neto Internal Alternate *
Eliana Zandonade Internal Examiner *
José Luiz Marques Rocha External Alternate *
Luciana Bronzi de Souza External Examiner *
Luciane Bresciani Salaroli Advisor *

Summary: INTRODUCTION: Rural populations have undergone changes inherent to work that affect
their living and health conditions and increase the prevalence of cardiovascular diseases. The
concomitant presence of overweight, hypertension, hyperglycemia and dyslipidemia constitute
the Metabolic Syndrome, which is linked to Insulin Resistance. The gold standard method for
determining IR is expensive and invasive, in this sense, the triglyceride/glucose (TyG) index
was developed, which is less expensive and uses parameters that are routinely measured. Thus,
the objective of this dissertation was to identify the cutoff point of the TyG Index according to
components of MS and to estimate its prevalence and associated factors in rural workers in
Espírito Santo. METHODS: This is a population-based cross-sectional study carried out with
family farmers in the city of Santa Maria de Jetibá/ES. The TyG index was calculated from the
equation: Ln [fasting triglycerides (mg/dL) x fasting glycemia (mg/dL)]/2, and MS was defined
using the NCEP-ATPIII and IDF criteria. The cutoff values of TyG Index for MS were obtained
using the Receiver Operating Characteristic (ROC) curve analysis with the area under the curve
(AUC) and the Youden Index. RESULTS: The sample consisted of 790 individuals of which
52.3% were male (N=413), 29.2% had 31 to 40 years old (N=231), 67.5% had less than 4 years
of study (N=533), 88.9% were white (n=702). The median TyG values were higher among
individuals diagnosed with MS (p<0.001), and increased according to the aggregation of the
components of MS. The TyG cutoff point was Ln 4.52, with a sensitivity of 82.96% and
specificity of 76.76%. The prevalence of IR was 33.8% (N = 267). TyG was associated with
age (p <0.001), body mass index (p <0.001) and schooling (p = 0.048). The age range of 31 to
40 years (OR = 1.723; 95% CI 1.02-2.89; p = 0.040), 41 to 50 years (OR = 3.357; 95% CI 1.95-
5.75; p <0.001) and over 50 years of age (OR = 2.535; 95% CI 1.43-4.48; p = 0.001), schooling
(OR = 2.290; 95% CI 1.27-4.09; p = 0.005), smoking (OR = 1.859; 95% CI 1.01-3.93; p =
0.043) and being overweight (OR = 3.822; 95% CI 2.66-5.48; p <0.001) significantly increased
the chance of presenting IR.

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